• The biological function of NPRA is demonstrated primarily

  2022-05-09

  

  The biological function of NPRA is demonstrated primarily through the ANP/BNP-dependent GC catalytic activity of the receptor and the production of cGMP, which is regulated by several factors, including hormones, growth factors, physiological milieu, and the ligand itself [26,34,[36], [37], [38], [3

• Cyclosporin D br Consequence physiological function of ROS d

  2022-05-07

  

  Consequence/physiological function of ROS-dependent inhibition of GSNOR Plants response to environmental changes induced by abiotic and biotic factors by enhanced accumulation of ROS resulting in temporary imbalance of the cellular redox homeostasis. This as oxidative stress/burst termed event tr

• br Introduction Adipose tissue AT in addition to its

  2022-05-07

  

  Introduction Adipose tissue (AT), in addition to its function as EZ Cap Reagent AG mg storage, is an important endocrine organ and it secretes adipokines (Ahima, 2006). Adipose tissue is related to different physiological processes such as energy metabolism, insulin sensitivity, and inflammation

• POM 1 In this study we examined

  2022-05-07

  

  In this study, we examined whether zebrafish ionocytes might also share other types of similarity in transport function with kidney cells. In addition to ion transport, mammalian kidney POM 1 also play key roles in xenobiotic elimination, through the action of ATP-Binding Cassette (ABC) transporter

• Administration of a fructose rich diet to normal rats

  2022-05-07

  

  Administration of a fructose-rich diet to normal rats induces insulin resistance and impaired glucose tolerance or diabetes, depending on treatment duration [23]. We have shown that development of these abnormalities as well as fat deposit in liver, are effectively prevented by co-administration of

• MRcKO mice showed a comparable degree of

  2022-05-07

  

  MRcKO mice showed a comparable degree of cardiac remodeling compared to control (MRf/f) mice. Moreover, the worse cardiac remodeling in pressure-overloaded GRcKO mice is not due to compensatory activation of cardiomyocyte MR, because GRMRdcKO mice displayed cardiac remodeling to the same extent as G

• br Materials and methods br Results br Discussion Common to

  2022-05-07

  

  Materials and methods Results Discussion Common to catfish fry production, high stocking densities as well as intensive handling during transport can result in low dissolved oxygen levels (Abdalla and Romaire, 1996; Torrans et al., 2003), which can result in fish stress. It is not known at

• Many studies support that Gli transcription

  2022-05-07

  

  Many studies support that Gli transcription factors are not solely regulated by Hh/smo signaling but are also influenced by crosstalk with other pathways, such as RAS, PI3K/AKT, transforming growth factor-b/SMAD, PKC, or extracellular signal-regulated kinase pathways which are downstream and indepen

• All data were analyzed using SAS software version

  2022-05-07

  

  All data were analyzed using SAS software (version 9.3, SAS Institute Inc., Cary, NC). Because of very low FFAR1 protein detection (at the detection limit or no signal) in 3 H-BHB cows, quantification was not possible within a linear range and therefore these animals were omitted from the statistica

• The pharmacokinetic properties of were amenable to

  2022-05-07

  

  The pharmacokinetic properties of 12 were amenable to oral dosing allowing in vivo comparison to 6. Compared to a maximum efficacious dose of 6 (60mg/kg), 12 demonstrated improved glycemic control during OGTT in high-fat fed/STZ treated (HF/STZ) and BDF/diet-induced obesity (DIO) mouse models of typ

• Several other assay parameters were also explored First the

  2022-05-07

  

  Several other assay parameters were also explored. First, the thermal dependence of the assay was investigated by measuring the specific activity at different temperatures (Fig. 7). That data show that enzymatic activity increases with increasing temperature. Interestingly, the observed rate increas

• Remarkably most of these molecules are also quite effective

  2022-05-07

  

  Remarkably, most of these molecules are also quite effective in interfering with the proliferation of the drug-resistant cancer cell lines, with IC50 values ranging from 0.59 to 2.93 μM against MCF-7/ADR cells, and from 0.160 to 1.17 μM against NSCLC-resistant H1975 cells. Among these molecules, com

• The present study was therefore conducted with

  2022-05-06

  

  The present study was therefore conducted with three aims; (1) we tested the effect of IRL-1620, a selective ETB receptor agonist, on the analgesic tolerance to morphine and oxycodone in mice; (2) we determined the expression of ETA receptors and ETB receptors in the DIG-11-dUTP of morphine and oxyc

• In order to establish proper folding and enzymatic

  2022-05-06

  

  In order to establish proper folding and enzymatic activity, G9a and GLP methyltransferases each contain four structural zinc ions. Both 5-Methoxy-CTP receptor contain two distinguishable types of zinc fingers; three Zn(II) ions are chelated in a triangular cluster by 9 cysteines (b, top left), whe

• br Conclusion H R H R and H R mRNAs

  2022-05-06

  

  Conclusion H1R, H2R, and H3R mRNAs were expressed in rat OE. Moreover, these three histamine receptors were present in the cytoplasm of ORNs in OE. This is the first report of the expression and localization of histamine receptors in mammalian OE. These findings indicate that histamine may play a

15617 records 440/1042 page Previous Next First page 上5页 436437438439440 下5页 Last page